Cell Research Publishes Findings on Poly (ADP-ribose) Mediating Asymmetric Division of Mouse Oocyte
PAR had been thought, over last two decades, to appear and function mainly under conditions of cellular stress such as DNA damage. This new study, however, identified cortical localization of PAR (under cell membrane) under physiological conditions, which functioned not in response to DNA damage.
Specifically removing cortical PAR in the oocyte leads to failure of asymmetric division
This study was first of its kind that involved PAR in the research of reproductive biology and may provide new strategies for quality assessment of oocyte and genetic intervention to improve success rates of in vitro maturation.
Interaction between cortical PAR and polar array microtubules mediates asymmetric division
See full article at https://www.nature.com/articles/s41422-018-0009-7.
Written by: Fan Xiaofei
Edited by: Liu Xin, Zhang Jiang
Source: Peking University Third Hospital