New procedure to inhibit relapse to drug seeking
A diagram showing UCS retrieval-extinction procedure
And now the group pushes this approach further. In a paper published in Nature Communication, they substitute the conditioned stimulus with non-contingent cocaine or methylphenidate injections. The novel process is called UCS retrieval-extinction procedure (UCS：unconditioned stimulus). It not only eliminates several limitations of the CS retrieval-extinction procedure, but also provides superior relapse prevention. Their data also show that this procedure is working through the regulation of AMPA receptor endocytosis in the basolateral amygdala, which enables further investigation into the mechanism of the new approach.Their work is supported in part by the National Basic Research Program of China and the Natural Science Foundation of China.
For the original Nature Communication paper, please check:
Written by: Li Yike
Edited by: Jin Panzhu
Source: PKU News (Chinese)